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15 The BGA links the enteric nervous system (ENS) and the central nervous system (CNS) via the hypothalamicpituitaryadrenal (HPA) axis, thereby driving the endocrine system to release hormones such as cortisol, which in turn exert bidirectional interactions with the gut immune system

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Ipamorelin acts on the distinct GHS-R1a receptor, amplifying the GH release signal through a separate intracellular pathway involving phospholipase C and protein kinase C

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